11 research outputs found
Self Determination Theory and Expressive Arts Therapy: A Path to Needs Satisfaction and Mindful Autonomous Motivation
This literature explores supporting mindful autonomous motivation by meeting basic psychological needs using expressive arts therapies. Self-determination theory was created from the extensive research of two psychologists, Edward Deci and Richard Ryan. The theory proposes that an increase in well-being and personal growth can be achieved by meeting the psychological needs for competence, relatedness, and autonomy (Reeve & Lee, 2019, p. 102). This paper investigates how various theories in expressive art therapy can be used to support psychological need satisfaction. The examination includes the therapeutic relationship, the expressive therapies approach and examples of populations impacted by frustrated need satisfaction. The populations discussed in this literature review include ex-cult members, nonbinary youth, hospitalized children, and incarcerated women
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Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
UnlabelledPancreas ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of all solid tumors, and thus new treatment strategies are urgently needed. Here, we report that targeting Bruton tyrosine kinase (BTK), a key B-cell and macrophage kinase, restores T cell-dependent antitumor immune responses, thereby inhibiting PDAC growth and improving responsiveness to standard-of-care chemotherapy. We report that PDAC tumor growth depends on cross-talk between B cells and FcRγ(+) tumor-associated macrophages, resulting in T(H)2-type macrophage programming via BTK activation in a PI3Kγ-dependent manner. Treatment of PDAC-bearing mice with the BTK inhibitor PCI32765 (ibrutinib) or by PI3Kγ inhibition reprogrammed macrophages toward a T(H)1 phenotype that fostered CD8(+) T-cell cytotoxicity, and suppressed PDAC growth, indicating that BTK signaling mediates PDAC immunosuppression. These data indicate that pharmacologic inhibition of BTK in PDAC can reactivate adaptive immune responses, presenting a new therapeutic modality for this devastating tumor type.SignificanceWe report that BTK regulates B-cell and macrophage-mediated T-cell suppression in pancreas adenocarcinomas. Inhibition of BTK with the FDA-approved inhibitor ibrutinib restores T cell-dependent antitumor immune responses to inhibit PDAC growth and improves responsiveness to chemotherapy, presenting a new therapeutic modality for pancreas cancer